Completely new technology enables the simultaneous identification of metals, as well organic and inorganic – Single Particle Explorer metal.ID + raman.ID combination installed at pilot customer site

For the first time rap.ID combined two independent spectroscopic methods to-
gether in an optical microscope. Laser Induced Breakdown Spectroscopy, metal.ID, which identifies the molecular structure, and raman.ID, which identifies the elemental composition of a particle, are joint together in order to create a fully automated system that can boast unknown sensitivity.

Aluminium particles give reliable spectra:

There is no expertise needed for this system. The unit autonomously performs the raman.ID and automatically thereafter performs the LIBS (metal.ID) measurement. This system provides a multi-faceted profile on all organic or inorganic substances.

Dry Powder Formulation Development Support by Identification of 60.000 Particles

Due to the increased sensitivity of the SPE inhaler unit you can design and develop your formulation down to a 500 nm resolution with high speed. Using the ratios provided you can compare the lactose carrier count to the active compound count. With less than 500 ms / 300 nm analysis spot thousands of individual particles can be measured and the material can be identified per hour.
It is as easy as a touch of a button to download our application note, which explains the blending experiment. It is interesting to note that the ratio of cellulose particles to active compound in a nasal spray formulation can be monitored and developed.

50 X more sensitivity for 2 µm Particles = 50 X more analysis speed Single Particle Explorer Inhaler launched

Originally developed in cooperation with the University of Jena for bacterial detection, the new UHT (ultra-high throughput) Raman laser spectrometer detector module now has a measurement sensitivity 50x higher than previous systems, reducing
measurement times to 1/50. Even particles as small as 0,5 µm provide a significant
spectrum within only 5 seconds. The concentration on small particles and high
throughput makes the system the ideal tool to streamline DPI and pMDI product
development, NDA and QbD and FP studies.

We have successfully adapted ISO 16232 parts cleanliness testing guidelines from the automotive industry to the pharmaceutical industry.

The ISO 16232 are a set of guidelines that establish standards for automotive and
hydraulic parts. rap.ID has successfully adapted parts of this ISO guideline in order
to create comparable standards for inhalers. Using innovative processes, rap.ID can
standardize and qualify the removal of particles from parts in order to test
cleanliness. Because inhalers are usually made of plastic material, the 2 µm particles found exhibit particular adhesive forces as well as behave uniquely by floating.

New delivered dose sampler with low blanks for the reliable collection of FPs in
Dry Powder Inhalers

A reliable and easy to clean sampling device is crucial for successful control of FPs.
rap.ID now has an inexpensive easy to clean device that allows you to collect
samples from a delivered dose. Flow rates up to 100 l/min can be applied. If the con-
tract testing customer wishes to perform the sampling in house they [the used FP
collector] can be shipped and the samples can be processed and analyzed reliably at
rap.ID laboratory in Berlin. The cleaned collectors will be shipped back to the
sponsor.